The present Guidance synthesizes strategic, technical, and operational lessons to support governments in the region that are exploring or implementing Debt-for-Nature Conversions (DFNC). The document translates these lessons into practical guidance to support countries in structuring effective transactions, strengthening inter-institutional coordination, and scaling up innovative financing mechanisms that connect debt management with environmental priorities. This Guidance is intended primarily for policymakers and technical teams in Ministries of Finance and Ministries of Environment, as well as other government agencies involved in debt management, climate policy, biodiversity conservation, and sustainable development planning. It provides both conceptual clarity and practical insights to support informed decision-making.