The interplay between fiscal and monetary policy has become increasingly central in shaping macroeconomic outcomes, particularly in an era of rising public debt and evolving policy challenges. This special issue of the Journal of Macroeconomics seeks to advance the frontier of research on the complex relationship between fiscal policy, monetary interventions, and debt sustainability. We are seeking for theoretical and empirical contributions that investigate the ramifications related to the interplay between fiscal and monetary policies and the long-term implications of fiscal and monetary policy strategies for macroeconomic stability. We welcome submissions that employ diverse methodological approaches, including structural models, quantitative macroeconomic methods, and empirical analyses using novel datasets.