The workshop gathers academics and policymakers to discuss recent scientific results concerning the end of the Great Moderation, the emergence of a new macroeconomic regime, and the associated challenges for economic policy. Topics of interest, without being exhaustive, concern inflation and stagflation, globalization and de-globalization, the slowdown in productivity growth, demographic and labor market trends, macroeconomic regimes and the financial-business cycle nexus, macroprudential and resilience policies, fiscal and monetary policy in a time of crisis, fiscal policy and financial stability, disinflationary supply-side policies and supply-side growth policies.